Reacción #46157

Ecuación de reacción

Piperonyl alcohol

Triethylamine

thionyl chloride

→

5-chloromethyl benzo[1,3]dioxol

Rendimiento 100.0%

Disolventes

benzene

Condiciones de reacción

Tratamiento posterior

1. 1
   ExtracciónThe reaction mixture was extracted with sodium bicarbonate and ethyl acetate
2. 2
   Otrothe organic layer was separated
3. 3
   Secadodried over anhydrous magnesium sulfate

Procedimiento

Piperonyl alcohol (10 g, 65.7 mmol) was dissolved in benzene. Triethylamine (11 ml, 78.8 mmol) and thionyl chloride (11 ml, 131.4 mmol) were added dropwise thereto and was stirred for 24 hours at 0° C. The reaction mixture was extracted with sodium bicarbonate and ethyl acetate, the organic layer was separated, and dried over anhydrous magnesium sulfate to obtain 5-chloromethyl benzo[1,3]dioxol (11.2 g, yield 100%).

Fuente