Reacción #461278

ord-592e86204a82466c93402b1bb0123d83

Ecuación de reacción

O=[N+]([O-])c1cc[n+]([O-])cc1F
3-fluoro-4-nitropyridine-N-oxide
CCc1ncc[nH]1
2-ethylimidazole
O=C(n1ccnc1)n1ccnc1
carbonyldiimidazole
→
CCc1ncc2c(=O)[nH]c3ccncc3n12
title compound
CCc1ncc2c(=O)[nH]c3ccncc3n12
1-Ethylimidazo[1,5-a]pyrido[4,5-e]pyrazine-4(5H)-one

Reactantes

O=[N+]([O-])c1cc[n+]([O-])cc1F
3-fluoro-4-nitropyridine-N-oxide
CCc1ncc[nH]1
2-ethylimidazole
O=C(n1ccnc1)n1ccnc1
carbonyldiimidazole

Reactivos

[Pd]
Pd-C

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Prepare by reaction of 3-fluoro-4-nitropyridine-N-oxide with 2-ethylimidazole followed by hydrogenation with Pd-C and cyclization with carbonyldiimidazole to provide the title compound.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US05166344uspto-grants-1992_11