Reacción #46123

Ecuación de reacción

7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxide

potassium carbonate

cyclopropylmethyl bromide

→

7-chloro-4-cyclopropylmethyl-4H-1,2,4-benzothiadiazine 1,1-dioxide

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture is heated
2. 2
   Temperaturaat reflux for 24 hours
3. 3
   OtroThe reaction mixture is evaporated under reduced pressure
4. 4
   FiltraciónThe insoluble material is collected by filtration
5. 5
   Lavadowashed with water
6. 6
   Otrodried
7. 7
   Otrois recrystallised from methanol

Procedimiento

To a solution of 7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxide (1 g) in acetonitrile (40 mL) there is added potassium carbonate (2.5 g) and cyclopropylmethyl bromide (0.7 mL) and the mixture is heated at reflux for 24 hours. The reaction mixture is evaporated under reduced pressure and the residue is taken up in water (40 mL). The insoluble material is collected by filtration, washed with water and dried and is recrystallised from methanol.

Fuente