Reacción #460743

Ecuación de reacción

Br2

3,4-dihydro-3,3-dimethyl-2H-1,5-benzodioxepine

→

7-bromo-3,4-dihydro-3,3-dimethyl-2H-1,5-benzodioxepine

Disolventes

CH2Cl2

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.WAITleft
2. 2
   Otroto react for 1 hour
3. 3
   workup.ADDITIONIt was then poured on to ice
4. 4
   Extracciónextracted with ether
5. 5
   LavadoWashing with NaHCO3 solution and water
6. 6
   Otrodrying
7. 7
   Otroevaporation

Procedimiento

8.55 g of 3,4-dihydro-3,3-dimethyl-2H-1,5-benzodioxepine (see Example 10) were dissolved in 70 ml of methylene chloride (CH2Cl2) and treated at 0° C. under an Argon atmosphere with a solution of 8.0 of Br2 in 30 ml of CH2Cl2. The mixture was warmed to room temperature and left to react for 1 hour. It was then poured on to ice and extracted with ether. Washing with NaHCO3 solution and water, drying and evaporation yielded 13.35 of of 7-bromo-3,4-dihydro-3,3-dimethyl-2H-1,5-benzodioxepine as a colorless oil which was 94.5% pure and which contained 4.7% of starting material; it was processed in the crude state.

Fuente