Reacción #460541

Ecuación de reacción

lithium diisopropylamide

1,3-bis(trifluoromethyl)benzene

N,N-dimethylformamide

→

2,4-Bis(trifluoromethyl)-benzaldehyde

Disolventes

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONare added dropwise
2. 2
   OtroThe internal temperature rises to -20° as a consequence of the exothermic reaction in spite of continuous cooling
3. 3
   OtroThe violet solution obtained

Procedimiento

A solution of 100 ml (0.21 mol) of lithium diisopropylamide in tetrahydrofuran is cooled under argon to -70° and at this temperature there are added dropwise thereto while stirring 31 ml (0.2 mol) of 1,3-bis(trifluoromethyl)benzene. The resulting dark red, viscous suspension is stirred at -70° for a further 30 minutes and then 31 ml (0.4 mol) of N,N-dimethylformamide are allowed to flow in rapidly. The internal temperature rises to -20° as a consequence of the exothermic reaction in spite of continuous cooling. The violet solution obtained is then processed further as described in Example 3a). 2,4-Bis(trifluoromethyl)-benzaldehyde is obtained.

Fuente