Reacción #46030

Ecuación de reacción

sodium hydride

2-fluoro-3-((4-propylcyclohexyl)phenyl)phenol

chloromethyl methyl ether

→

2-fluoro-3-((4-propylcyclohexyl)phenyl)-1-methoxymethoxybenzene

Rendimiento 107.6%

Disolventes

THF

water

water

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGby stirring at ambient temperature for 4 hours
2. 2
   OtroAfter terminating
3. 3
   Otrothe reaction
4. 4
   Extracciónthe aqueous layer was extracted with toluene, which
5. 5
   workup.ADDITIONwas added to the organic layer
6. 6
   Lavadothe organic layer was washed with a saturated salt solution
7. 7
   Secadodried over anhydrous magnesium sulfate
8. 8
   workup.DISTILLATIONThe solvent was distilled off

Procedimiento

Under a nitrogen atmosphere, 1.52 g of sodium hydride was added to 9.45 g of 2-fluoro-3-((4-propylcyclohexyl)phenyl)phenol (5) dissolved in 60 mL of THF cooling with iced water, and the mixture was stirred at ambient temperature for 30 minutes. 3.07 g of chloromethyl methyl ether was added to the solution under cooling with iced water, followed by stirring at ambient temperature for 4 hours. After terminating the reaction by pouring water into the reaction solution, the aqueous layer was extracted with toluene, which was added to the organic layer, and the organic layer was washed with a saturated salt solution and then dried over anhydrous magnesium sulfate. The solvent was distilled off to obtain 11.6 g of 2-fluoro-3-((4-propylcyclohexyl)phenyl)-1-methoxymethoxybenzene (6).

Fuente