Reacción #46022

Ecuación de reacción

{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}phenol

Cs2CO3

mesylate

→

phenyl ether

Disolventes

DMF

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroobtained above and the reaction mixture
2. 2
   TemperaturaThe reaction mixture was then cooled to rt
3. 3
   Extracciónthe product was extracted with DCM
4. 4
   SecadoThe organic layer was dried over anhydrous sodium sulfate
5. 5
   Concentraciónconcentrated in vacuo

Procedimiento

{1-[4-(4-Chloro-phenoxy)-phenyl]-2-isobutyl-1H-imidazol-4-yl}phenol (2 mmol) was added to a solution of Cs2CO3 (10 eq., 20 mmol) in anhydrous DMF (5 ml). This was followed by addition of the mesylate obtained above and the reaction mixture was heated to 90° C. for 2-3 h. The reaction mixture was then cooled to rt, diluted with cold water and the product was extracted with DCM. The organic layer was dried over anhydrous sodium sulfate and concentrated in vacuo to give desired phenyl ether.

Fuente