Reacción #459915

Ecuación de reacción

5-bromo-2-pyridone

potassium thiophenoxide

→

5-(Phenylthio)-2-pyridone

Disolventes

water

N-methylpyrrolidinone

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux for 12 hours under a nitrogen atmosphere
2. 2
   TemperaturaThe reaction mixture is cooled
3. 3
   FiltraciónThe product is collected by filtration
4. 4
   Lavadowashed with water
5. 5
   Secadodried to yeild 5-(phenylthio)-2-pyridone

Procedimiento

A solution of 5-bromo-2-pyridone (17.3 g 0.1 mole) in N-methylpyrrolidinone (250 ml.) and potassium thiophenoxide (18.1 g, 0.12 mole) is heated at reflux for 12 hours under a nitrogen atmosphere. The reaction mixture is cooled and diluted with water. The product is collected by filtration, washed with water and dried to yeild 5-(phenylthio)-2-pyridone.

Fuente