Reacción #459779

Ecuación de reacción

t-butyl azidoformate

triethylamine

2-bromoethylamine hydrobromide

→

N-Carbo-t-butoxy-2-bromoethylamine

Disolventes

methylene chloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtración, then filtered
2. 2
   ConcentraciónThe filtrate was concentrated to a small volume
3. 3
   SecadoThe ether layer was dried
4. 4
   workup.DISTILLATIONdistilled under reduced pressure
5. 5
   Otrocollecting the fraction b.p. 92°-94°/0.9 mm as N-carbo-t-butoxy-2-bromoethylamine (1.756 g.)

Procedimiento

A mixture of t-butyl azidoformate (15.81 g) and triethylamine (30 ml) was added dropwise to a stirred suspension of 2-bromoethylamine hydrobromide (20.5 g.); in methylene chloride (100 ml.). The mixture was stirred for 3 hr., then filtered. The filtrate was concentrated to a small volume, and the residue was distributed between ether and water. The ether layer was dried, then distilled under reduced pressure, collecting the fraction b.p. 92°-94°/0.9 mm as N-carbo-t-butoxy-2-bromoethylamine (1.756 g.)

Fuente