Reacción #459374

ord-cdf05f39d8c5430eae2c8181c52744c2

Ecuación de reacción

Cl.N=C(N=C(N)N)N1CCOCC1
moroxydine hydrochloride
O=C(O)/C=C\C(=O)O
maleic acid
→
N=C(N)/N=C(\N)N1CCOCC1.O=C([O-])/C=C\C(=O)[O-]
moroxydine maleate
N=C(N)/N=C(\N)N1CCOCC1
moroxydine

Reactantes

Cl.N=C(N=C(N)N)N1CCOCC1
moroxydine hydrochloride
O=C(O)/C=C\C(=O)O
maleic acid

Reactivos

Ninguno

Disolventes

O
water

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Otroevaporated to crystallization

Procedimiento

Alternatively, the free base of moroxydine is prepared, e.g.: 2.1 g. moroxydine hydrochloride is dissolved in 100 ml. water and treated with an anion exchange resin. The resulting solution is neutralized, for example, with maleic acid and evaporated to crystallization yielding moroxydine maleate.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US04089957uspto-grants-1978_05