Reacción #45818

Ecuación de reacción

Methyl 4-acetylamino-5-bromo-3-(3,3-dimethyl-1-butynyl)salicylate

→

compound

Rendimiento 82.0%

Methyl 4-acetylamino-5-bromo-2-tert-butyl-1-benzofuran-7-carboxylate

Rendimiento 82.0%

Disolventes

triethylamine

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawith heating
2. 2
   Temperaturaunder reflux for 2 hours
3. 3
   Otrothe reaction liquid
4. 4
   Concentraciónwas concentrated under reduced pressure

Procedimiento

Methyl 4-acetylamino-5-bromo-3-(3,3-dimethyl-1-butynyl)salicylate (I-250) (202 mg, 0.55 mmol) was dissolved in a mixed liquid of triethylamine (4 ml) and toluene (10 ml), and stirred with heating under reflux for 2 hours. After cooling to room temperature, the reaction liquid was concentrated under reduced pressure, the resulting residue was subjected to column chromatography, and the eluate with n-hexane/ethyl acetate (2:1) gave the entitled compound (165 mg, 82%) as a white solid.

Fuente