Reacción #4579

Ecuación de reacción

sodium hydroxide

α-[3-n-propyl-6H-pyrrolo[3,4-b]pyridine-5,7-dione-6-yl]-α-isopropyl-α-methyl-acetamide

water

→

title compound

3-isopropyl-3-methyl-7-n-propyl-3H-imidazo[1',2':1,2]pyrrolo[3,4-b]pyridine-2,5-dione

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter the reaction solution has cooled
2. 2
   Filtraciónit is filtered through silica gel
3. 3
   Lavadothe filtrate is washed with ethyl acetate
4. 4
   Concentraciónconcentrated by evaporation
5. 5
   OtroThe residue is recrystallised from ethyl acetate/petroleum ether

Procedimiento

With the simultaneous addition of 0.5 g of powdered sodium hydroxide, a solution of α-[3-n-propyl-6H-pyrrolo[3,4-b]pyridine-5,7-dione-6-yl]-α-isopropyl-α-methyl-acetamide (m.p.: 82° C.) in 100 ml of toluene is heated under reflux for 2 hours in a water separator. After the reaction solution has cooled, it is filtered through silica gel and the filtrate is washed with ethyl acetate and then concentrated by evaporation. The residue is recrystallised from ethyl acetate/petroleum ether, affording 13.1 g of the title compound which melts at 116° C.

Fuente