Reacción #45788

Ecuación de reacción

2-(benzyloxy)-N-(5-cyano-2-fluoro-3-hydroxy-6-methylbiphenyl-4-yl)acetamide

→

N-(5-Cyano-2-fluoro-3-hydroxy-6-methyl-biphenyl-4-yl)-2-hydroxyacetamide

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter the reaction
2. 2
   Otrothe insoluble matter was removed by filtration
3. 3
   Concentraciónthe filtrate was concentrated under reduced pressure
4. 4
   Otroto obtain the entitled compound
5. 5
   OtroNot purified
6. 6
   Otrothis was used in the next reaction as such

Procedimiento

A catalyst 10%-palladium carbon (40.0 mg) was added to an ethanol (10 ml) solution of 2-(benzyloxy)-N-(5-cyano-2-fluoro-3-hydroxy-6-methylbiphenyl-4-yl)acetamide (I-89) (120 mg, 0.307 mmol), followed by stirring under hydrogen atmosphere at room temperature for 15 hours. After the reaction, the insoluble matter was removed by filtration, the filtrate was concentrated under reduced pressure to obtain the entitled compound. Not purified, this was used in the next reaction as such.

Fuente