Reacción #4577

Ecuación de reacción

methyl 5-chlorooxindole-3-carboxylate

phenylisocyanate

→

Methyl 1-N-(phenyl)carbamoyl-5-chlorooxindole-3-carboxylate

Disolventes

toluene

—

petroleum ether

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheated
2. 2
   Temperaturato reflux overnight
3. 3
   TemperaturaThe reaction mixture was cooled
4. 4
   Otroto give
5. 5
   Filtraciónafter filtration
6. 6
   Otrodrying

Procedimiento

To 6.0 g. (0.027 mole) of methyl 5-chlorooxindole-3-carboxylate in 200 ml. of toluene was added 5.25 ml. (0.048 mole) of phenylisocyanate and the resulting reaction mixture heated to reflux overnight. The reaction mixture was cooled and diluted with petroleum ether to give, after filtration and drying, 2.0 g. of the desired product.

Fuente