Reacción #45767

Ecuación de reacción

Lawesson's reagent

4-cyano-7-fluoro-5-methyl-6-phenyl-1,3-benzoxazole-2-carboxamide

→

compound

Rendimiento 41.8%

4-Cyano-7-fluoro-5-methyl-6-phenyl-1,3-benzoxazole-2-carbothioamide

Rendimiento 41.8%

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaby heating
2. 2
   TemperaturaAfter cooling to room temperature
3. 3
   Otrothe reaction liquid
4. 4
   Concentraciónwas concentrated
5. 5
   Otrothe resulting residue was purified by silica gel column chromatography (eluent, chloroform:ethyl acetate=20:1→10:1)

Procedimiento

Lawesson's reagent (458 mg, 1.13 mmol) was added to a toluene solution of 4-cyano-7-fluoro-5-methyl-6-phenyl-1,3-benzoxazole-2-carboxamide (I-196) (304 mg, 1.03 mmol), followed by heating under reflux in an oil bath at 125° C. for 10 minutes. After cooling to room temperature, the reaction liquid was concentrated, and the resulting residue was purified by silica gel column chromatography (eluent, chloroform:ethyl acetate=20:1→10:1) to obtain the entitled compound (134 mg, 41.8%) as a yellow solid.

Fuente