Reacción #457133

Ecuación de reacción

(+)-3-ethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline

isopropanol-HCl

→

(+)-3-ethyl-1,2,3,4-tetrahydroisoquinolin-7-amine dihydrochloride

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe catalyst was removed by filtration
2. 2
   Otrothe solvent evaporated

Procedimiento

To a pressure bottle charged with (+)-3-ethyl-7-nitro-1,2,3,4-tetrahydroisoquinoline (3.5 g) dissolved in methanol (100 ml) and saturated isopropanol-HCl (20 ml) was added 10% Pd--C (250 mg), and the reaction was hydrogenated for 1 h. The catalyst was removed by filtration and the solvent evaporated to give (+)-3-ethyl-1,2,3,4-tetrahydroisoquinolin-7-amine dihydrochloride (3.4 g), m.p. 199-200° C., [α]D +68.4° (c 0.976, methanol).

Fuente