Reacción #45673

Ecuación de reacción

N-bromosuccinimide

4-cyano-6-[1-(ethoxy)ethenyl]-7-fluoro-N,N,5-trimethyl-1,3-benzoxazole-2-carboxamide

→

6-Bromoacetyl-4-cyano-7-fluoro-N,N,5-trimethyl-1,3-benzoxazole-2-carboxamide

Disolventes

tetrahydrofuran water

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was evaporated away under reduced pressure
2. 2
   workup.DISSOLUTIONthe resulting residue was dissolved in ethyl acetate
3. 3
   Lavadothe solution was washed with water

Procedimiento

Next, at room temperature, N-bromosuccinimide (2.10 g, 11.8 mmol) was added to a tetrahydrofuran/water (178 ml/11 ml) mixed solution of the obtained 4-cyano-6-[1-(ethoxy)ethenyl]-7-fluoro-N,N,5-trimethyl-1,3-benzoxazole-2-carboxamide (3.56 g, 11.2 mmol), and stirred for 20 minutes. The solvent was evaporated away under reduced pressure, and the resulting residue was dissolved in ethyl acetate, and the solution was washed with water.

Fuente