Reacción #45670

Ecuación de reacción

2-amino-5-bromo-4-fluoro-3-hydroxy-6-methylbenzonitrile

ethyl triethoxyacetate

→

compound

Rendimiento 80.0%

Ethyl 6-bromo-4-cyano-7-fluoro-5-methyl-1,3-benzoxazole-2-carboxylate

Rendimiento 80.0%

Disolventes

n-hexane

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling
2. 2
   Filtraciónthe precipitated solid was collected by filtration
3. 3
   Lavadowashed in diethyl ether

Procedimiento

Under nitrogen atmosphere, a mixture of 2-amino-5-bromo-4-fluoro-3-hydroxy-6-methylbenzonitrile (I-75) (6.67 g, 27.2 mmol) and ethyl triethoxyacetate (24.0 g, 54.4 mmol) was stirred at 130° C. for 15 hours. After cooling, n-hexane was added to the reaction liquid, and the precipitated solid was collected by filtration. The obtained solid was suspended and washed in diethyl ether to obtain the entitled compound (7.10 g, 80%) as a pale dark brown solid.

Fuente