Reacción #456383

Ecuación de reacción

sodium bicarbonate

N-[(1,1-dimethylethoxy) carbonyl]-O-[(trifluoromethyl) sulphonyl]-L-tyrosine

(S)N-(2-(mercaptomethyl)-1-oxo-3-phenylpropyl]4- (2-thienyl)L-phenylalanine

naphthalene boronic acid

→

expected product

(S)N-[2-(mercaptomethyl)-1-oxo-3-phenylpropyl]4-(1-naphthyl)-L-phenylalanin

Disolventes

toluene

Condiciones de reacción

Procedimiento

The operation is carried out as in Stage 1 of Example 10 starting with methyl ester of N-[(1,1-dimethylethoxy) carbonyl]-O-[(trifluoromethyl) sulphonyl]-L-tyrosine (prepared as indicated in Stage 1 of Example 10), 10 ml of toluene, 282 mg of naphthalene boronic acid and 169.7 mg of sodium bicarbonate, the solution is agitated for 15 minutes, then 94.77 mg of 5-tetrakis (triphenylphosphine) is added. In this way 165.7 mg of expected product is obtained.

Fuente