Reacción #455956

ord-6f22a2d4b4be4551b0a9234ef1aa3490

Ecuación de reacción

COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)cc(C#N)cc2OCCO)c1
4-tert-butyl-N-[5-cyano-3-(2-hydroxy-ethoxy)-2-(3-methoxy-phenoxy)-phenyl]-benzenesulphonamide
[N-]=[N+]=[N-].[Na+]
sodium azide
→
COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)cc(-c3nnn[nH]3)cc2OCCO)c1
4-tert-butyl-N-[3-(2-hydroxy-ethoxy)-2-(3-methoxy-phenoxy)-5-(1 H-tetrazol-5-yI)-phenyl]-benzenesulphonamide

Reactantes

COc1cccc(Oc2c(NS(=O)(=O)c3ccc(C(C)(C)C)cc3)cc(C#N)cc2OCCO)c1
4-tert-butyl-N-[5-cyano-3-(2-hydroxy-ethoxy)-2-(3-methoxy-phenoxy)-phenyl]-benzenesulphonamide
[N-]=[N+]=[N-].[Na+]
sodium azide

Reactivos

Ninguno

Disolventes

CN(C)C=O
N,N-dimethylformamide

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

In analogy to Example 140, by reacting 4-tert-butyl-N-[5-cyano-3-(2-hydroxy-ethoxy)-2-(3-methoxy-phenoxy)-phenyl]-benzenesulphonamide and sodium azide in N,N-dimethylformamide there was obtained 4-tert-butyl-N-[3-(2-hydroxy-ethoxy)-2-(3-methoxy-phenoxy)-5-(1 H-tetrazol-5-yI)-phenyl]-benzenesulphonamide as a white foam.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06133442uspto-grants-2000_10