Reacción #45579

Ecuación de reacción

N-iodosuccinimide

acetic acid

4-bromo-3-fluoro-2-methoxy-5-methylaniline

→

4-Bromo-3-fluoro-6-iodo-2-methoxy-5-methylphenylamine

Disolventes

brine

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónfollowed by extraction twice with ethyl acetate
2. 2
   Lavadothe organic layer was washed three times with saturated brine
3. 3
   Secadodried over anhydrous magnesium sulfate

Procedimiento

N-iodosuccinimide (1.91 g, 8.5 mmol) was added to an acetic acid (40 ml) solution of 4-bromo-3-fluoro-2-methoxy-5-methylaniline (I-43) (1.90 g, 8.1 mmol), followed by stirring at room temperature for 67 hours. Saturated brine was added to the reaction liquid, followed by extraction twice with ethyl acetate, the organic layer was washed three times with saturated brine, dried over anhydrous magnesium sulfate.

Fuente