Reacción #453717

Ecuación de reacción

Sodium hydride

3-azabicyclo[3.1.0]hexane-2,4dione

1-bromo-2-cyclohexylethane

→

title compound

3-[2-(Cyclohexyl)ethyl]-3-azabicyclo[3.1.0]hexane-2,4-dione

Disolventes

dimethylformamide

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with toluene (20 ml)
2. 2
   ExtracciónThe organic extract
3. 3
   Lavadowas washed with water (15 ml)
4. 4
   Secadodried (MgSO4)
5. 5
   Otroevaporated in vacuo
6. 6
   workup.DISTILLATIONThe residue was purified by Kugelrohr distillation (boiling point 130-140° C. @ 0.1 mmHg)

Procedimiento

Sodium hydride (0.11 g) was added to a solution of 3-azabicyclo[3.1.0]hexane-2,4dione (0.3 g) and 1-bromo-2-cyclohexylethane (0.52 g) in dimethylformamide (5 ml) and the resulting mixture was stirred at room temperature under a nitrogen atmosphere for 16 hours. The mixture was diluted with water (15 ml) and then extracted with toluene (20 ml). The organic extract was washed with water (15 ml), dried (MgSO4) and evaporated in vacuo. The residue was purified by Kugelrohr distillation (boiling point 130-140° C. @ 0.1 mmHg) to give the title compound as a colourless oil.

Fuente