Reacción #452447

Ecuación de reacción

Potassium carbonate

3,7-dimethyl-1,6-octadien-3-yl 3-oxo-butyrate

benzyl chloride

→

desired compound

3,7-dimethyl-1,6-octadien-3-yl 3-oxo-2-benzylbutyrate

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   Otrofitted with a magnetic stirrer, condenser and argon inlet
2. 2
   TemperaturaThe mixture is heated
3. 3
   Temperaturato reflux for 18 h
4. 4
   FiltraciónThe cooled mixture is filtered
5. 5
   Concentraciónconcentrated by rotary evaporation
6. 6
   OtroThe resulting oil is purified on silica gel

Procedimiento

Potassium carbonate (3.92 g, 0.028 mol), 3,7-dimethyl-1,6-octadien-3-yl 3-oxo-butyrate (4.80 g, 0.030 mol), benzyl chloride (4.80 g, 0.038 mol) and acetone (15 mL) are placed in a 50 mL round-bottomed flask fitted with a magnetic stirrer, condenser and argon inlet. The mixture is heated to reflux for 18 h. The cooled mixture is filtered and concentrated by rotary evaporation. The resulting oil is purified on silica gel to yield the desired compound. Structure is confirmed by thin layer chromatography and 1H and 13C NMR.

Fuente