Reacción #450462

Ecuación de reacción

4-methoxybenzenesulfonamide

4-(2-bromoethyl)benzoyl chloride

→

N-[4-(2-bromoethyl)benzoyl]-4-methoxybenzenesulfonamide

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheated
2. 2
   Temperaturato reflux at which time solution
3. 3
   TemperaturaThe solution was heated
4. 4
   Temperaturaat reflux for 16.5 hrs
5. 5
   Otrowere acidic during reaction
6. 6
   TemperaturaAfter this time, the solution was cooled
7. 7
   Concentraciónconcentrated to an oil
8. 8
   workup.DISSOLUTIONThe oil was dissolved in 3:7 heptane
9. 9
   Temperaturatoluene and cooled
10. 10
    OtroSolid crystallized
11. 11
    Otrowas collected
12. 12
    Lavadowashed with ligroine
13. 13
    Otrodried

Procedimiento

A mixture of 18.72 g (0.10 mol) of 4-methoxybenzenesulfonamide, 24.75 g (0.10 mol) of 4-(2-bromoethyl)benzoyl chloride and 200 ml of toluene was stirred and heated to reflux at which time solution was achieved. The solution was heated at reflux for 16.5 hrs. The vapors emitted from the condenser were acidic during reaction. After this time, the solution was cooled and concentrated to an oil. The oil was dissolved in 3:7 heptane:toluene and cooled. Solid crystallized and was collected, washed with ligroine and dried.

Fuente