Reacción #44987

Ecuación de reacción

t-Butyl 4-[trans-4-(methoxycarbonyl)cyclohexyl]-3-oxopiperazine-1-carboxylate

sodium hydroxide

→

title compound

Rendimiento 101.6%

Trans-4-[4-(t-butoxycarbonyl)-2-oxopiperazin-1-yl]cyclohexanecarboxylic acid

Rendimiento 101.6%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooling
2. 2
   Concentraciónconcentrated under reduced pressure
3. 3
   workup.ADDITIONWater and chloroform are poured to the residue, and aqueous layer
4. 4
   workup.ADDITIONis acidified by addition of 2 N hydrochloric acid
5. 5
   OtroThe organic layer is separated
6. 6
   Lavadowashed with saturated brine
7. 7
   Secadodried over sodium sulfate
8. 8
   OtroThe solvent is removed by evaporation under reduced pressure

Procedimiento

t-Butyl 4-[trans-4-(methoxycarbonyl)cyclohexyl]-3-oxopiperazine-1-carboxylate (385 mg) obtained in Reference Example 71 (3) is dissolved in methanol (8 ml), and thereto is added 1 N aqueous sodium hydroxide solution (3.4 ml) under ice-cooling. The reaction solution is stirred at room temperature for 20 hours and concentrated under reduced pressure. Water and chloroform are poured to the residue, and aqueous layer is acidified by addition of 2 N hydrochloric acid. The organic layer is separated, washed with saturated brine and dried over sodium sulfate. The solvent is removed by evaporation under reduced pressure to give the title compound (375 mg).

Fuente