Reacción #4478

Ecuación de reacción

1,3-Cyclohexanedione

product

[4-(Phenylmethoxy)phenyl]hydrazine hydrochloride

→

title compound

Rendimiento 38.4%

1,2,3,9-Tetrahydro-6-(phenylmethoxy)-4H-carbazol-4-one

Rendimiento 38.4%

Disolventes

ethanol

water

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaheated
2. 2
   Temperaturato reflux for 14 h
3. 3
   Temperaturato cool
4. 4
   Filtraciónthe precipitate filtered
5. 5
   Lavadowashed with isopropyl acetate and ether
6. 6
   Otroto give a solid
7. 7
   OtroRecrystallisation from methanol

Procedimiento

1,3-Cyclohexanedione (3.1 g) and the product of Stage (i) (5.6 g) in ethanol (196 ml) and water (39 ml) was stirred at room temperature for 3 h and then heated to reflux for 14 h. The resulting solution was allowed to cool, poured into water (500 ml) and the precipitate filtered and washed with isopropyl acetate and ether to give a solid. Recrystallisation from methanol gave the title compound as a solid (2.5 g) m.p. 235°-237°.

Fuente