Reacción #4476

Ecuación de reacción

water

potassium carbonate

product

1,2,3,9-Tetrahydro-6-methoxy-4H-carbazol-4-one

Dimethyl sulphate

→

title compound

Rendimiento 78.2%

1,2,3,9-Tetrahydro-6-methoxy-9-methyl-4H-carbazol-4-one

Rendimiento 78.2%

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture was heated
2. 2
   Temperaturato reflux for 4 h
3. 3
   Filtraciónthe resulting precipitate filtered off

Procedimiento

Anhydrous potassium carbonate (2.24 g) was added to a solution of the product of Stage (i) (3 g) in acetone (30 ml) at room temperature and stirred for 30 min. Dimethyl sulphate (1.6 ml) was added and the mixture was heated to reflux for 4 h. The resulting solution was poured into water (150 ml) and the resulting precipitate filtered off to give the title compound as a solid (2.5 g), m.p. 150°-151°.

Fuente