Reacción #44759

Ecuación de reacción

2,2,3,3,3-pentafluoropropyl 4-methylbenzenesulfonate

4-hydroxybenzaldehyde

potassium carbonate

→

4-(2,2,3,3,3-pentafluoropropoxy)benzaldehyde

Rendimiento 30.2%

Disolventes

ethyl acetate

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added
2. 2
   workup.STIRRINGThe mixture was stirred
3. 3
   Temperaturaheated at 100° C. for 7 h
4. 4
   Temperaturato cool
5. 5
   Lavadowashed with water (3×) and brine
6. 6
   Concentraciónconcentrated
7. 7
   OtroPurification by flash chromatography on silica gel using a gradient of ethyl acetate in hexane

Procedimiento

A solution of 4-hydroxybenzaldehyde (2 g, 16.7 mmol) in DMF (33 mL) was stirred as solid potassium carbonate (4.1 g, 29.7 mmol) was added, and the reaction mixture was then stirred at RT. After 30 min, solid 2,2,3,3,3-pentafluoropropyl 4-methylbenzenesulfonate (5 g, 16.4 mmol) was added into the reaction mixture. The mixture was stirred and heated at 100° C. for 7 h. The reaction mixture was allowed to cool, diluted with ethyl acetate, washed with water (3×) and brine, and concentrated. Purification by flash chromatography on silica gel using a gradient of ethyl acetate in hexane afforded 4-(2,2,3,3,3-pentafluoropropoxy)benzaldehyde (1.26 g).

Fuente