Reacción #44735

Ecuación de reacción

ethyl acetate

6-chloro-N4-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-phenyl]pyrimidine-2,4-diamine

6-Chloro-N4-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]pyrimidine-2,4-diamine

3-[(2,4-dimethoxybenzyl)amino]propan-1-ol

TFA

→

3-[(2-Amino-6-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]amino}-pyrimidin-4-yl)amino]propan-1-ol

Disolventes

DCM

1-butanol

N-ethyl-diisopropylamine

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroVolatile components are removed under reduced pressure
2. 2
   Otrothe residue is purified by preparative HPLC
3. 3
   OtroThe substrate obtained
4. 4
   Extracciónextracted with sat. sodium carbonate solution
5. 5
   SecadoThe organic phase is dried over sodium sulfate
6. 6
   Otrothe solvent is removed under reduced pressure
7. 7
   OtroThe residue is purified by preparative HPLC

Procedimiento

78 mg (0.21 mmol) of 6-chloro-N4-[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-phenyl]pyrimidine-2,4-diamine (from example 60), 190 mg (0.84 mmol) of 3-[(2,4-dimethoxybenzyl)amino]propan-1-ol in 1 ml of 1-butanol and 0.37 ml of N-ethyl-diisopropylamine are, in a closed pressure vessel, heated at 130° C. overnight. Volatile components are removed under reduced pressure, and the residue is purified by preparative HPLC. The substrate obtained is taken up in 2 ml of DCM, and 0.5 ml of TFA is added. The mixture is stirred at RT for 20 min and then poured into ethyl acetate and extracted with sat. sodium carbonate solution. The organic phase is dried over sodium sulfate and the solvent is removed under reduced pressure. The residue is purified by preparative HPLC.

Fuente