Reacción #4471

Ecuación de reacción

product

6-Fluoro-1,2,3,9-tetrahydro-4H-carbazol-4-one

potassium carbonate

dimethylsulphate

→

title compound

Rendimiento 97.5%

6-Fluoro-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one

Rendimiento 97.5%

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe mixture was concentrated to one half of its volume
2. 2
   FiltraciónThe mixture was filtered off
3. 3
   Lavadowashed with water (50 ml)
4. 4
   Otroair-dried for 1 h
5. 5
   Secadodried in vacuo over phosphorus pentoxide

Procedimiento

The product of Stage (ii) (7.28 g), potassium carbonate (9.90 g), acetone (70 ml), and dimethylsulphate (5.1 ml) were vigorously stirred at room temperature overnight under nitrogen. The mixture was concentrated to one half of its volume and then stirred with water (350 ml) for 30 min. The mixture was filtered off, washed with water (50 ml), air-dried for 1 h, and dried in vacuo over phosphorus pentoxide to give the title compound as needles (7.59 g), m.p. 157.5°-158.5°.

Fuente