Reacción #44697

Ecuación de reacción

2,6-difluorobenzonitrile

potassium carbonate

3-chloro-4-hydroxyaniline

→

2-(4-Amino-2-chlorophenoxy)-6-fluorobenzonitrile

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture is heated
2. 2
   Temperaturaat reflux for 45 min
3. 3
   FiltraciónThe mixture is filtered
4. 4
   Lavadothe filtercake is washed with ethyl acetate and DCM
5. 5
   OtroThe solvent is removed under reduced pressure

Procedimiento

1.00 g (7.19 mmol) of 2,6-difluorobenzonitrile is initially charged in 10 ml of acetonitrile. 1.99 g (14.4 mmol) of potassium carbonate and 1.03 g (7.19 mmol) of 3-chloro-4-hydroxyaniline are added, and the mixture is heated at reflux for 45 min. The mixture is filtered and the filtercake is washed with ethyl acetate and DCM. The solvent is removed under reduced pressure and the residue is by column chromatography (silica gel 60, gradient column: mobile phase: DCM:petroleum ether=2:1, then DCM).

Fuente