Reacción #446754

Ecuación de reacción

4-di(2-acetyloxyethyl)aminobenzaldehyde

4-nitrophenyl acetic acid

piperdine

→

4-di(2-hydroxyethyl)amino-4'-nitrostilbene

Disolventes

dimethyl formamide

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONA mixture of the crude
2. 2
   Otroreaction product of the previous step, viz
3. 3
   ConcentraciónNext, the reaction mixture was concentrated by evaporation at 70° C. to a thick red oil, which
4. 4
   workup.DISSOLUTIONThe residue was dissolved in 2.5 l of dimethyl formamide
5. 5
   workup.ADDITIONThen there was added a solution of 320 g of sodium hydroxide in 800 ml of water
6. 6
   OtroThe resulting reaction mixture
7. 7
   Temperaturawas then heated for 16 hours to 100° C.
8. 8
   FiltraciónThe precipitated product was filtered off
9. 9
   Lavadothoroughly after-washed three times
10. 10
    OtroAfter drying the crude
11. 11
    Otroreaction product
12. 12
    Otrowas crystallized from 250 ml of dimethyl formamide and 500 ml of dichloromethane

Procedimiento

A mixture of the crude reaction product of the previous step, viz. 4-di(2-acetyloxyethyl)aminobenzaldehyde, 270 g of 4-nitrophenyl acetic acid, 2 l of dimethyl formamide, and 100 ml of piperdine was stirred for 4 days at 20°-25° C. Next, the reaction mixture was concentrated by evaporation at 70° C. to a thick red oil, which was titrated three times, each time with 1 l of n-hexane. The residue was dissolved in 2.5 l of dimethyl formamide. Then there was added a solution of 320 g of sodium hydroxide in 800 ml of water. The resulting reaction mixture was then heated for 16 hours to 100° C. and subsequently poured into 10 l of ice water. The precipitated product was filtered off and thoroughly after-washed three times, each time with 1 l of water. After drying the crude reaction product was crystallized from 250 ml of dimethyl formamide and 500 ml of dichloromethane. The resulting yield of 4-di(2-hydroxy-ethyl) amino-4'-nitrostilbene was 190 g with a melting point of 184°-185° C. Calculated on N,N-di(2-hydroxyethyl)aniline this is 58% of theory.

Fuente