Reacción #44636

Ecuación de reacción

Trifluoroacetic acid

methylene chloride

[(1R,2R)-2-tert-butyldiphenylsilanyloxy-1-(3,4,5-trifluorophenyl)propyl]carbamic acid tert-butyl ester

sodium hydrogencarbonate

→

title compound

Rendimiento 91.1%

(1R,2R)-2-tert-butyldiphenylsilanyloxy-1-(3,4,5-trifluorophenyl)propylamine

Rendimiento 91.1%

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe resulting reaction solution
2. 2
   OtroThe organic layer was separated
3. 3
   Lavadowashed with a saturated sodium hydrogencarbonate aqueous solution and with saturated saline in this order
4. 4
   Concentraciónconcentrated under reduced pressure

Procedimiento

Trifluoroacetic acid (0.5 mL) was added to a methylene chloride solution (2 mL) of [(1R,2R)-2-tert-butyldiphenylsilanyloxy-1-(3,4,5-trifluorophenyl)propyl]carbamic acid tert-butyl ester (370 mg). The resulting reaction solution was stirred at room temperature for 11 hr, and a saturated sodium hydrogencarbonate aqueous solution and ethyl acetate were added thereto. The organic layer was separated, washed with a saturated sodium hydrogencarbonate aqueous solution and with saturated saline in this order, and concentrated under reduced pressure to give 275 mg of the title compound. The physical property values of this compound were as follows:

Fuente