Reacción #446287

Ecuación de reacción

Diethyl 2-ethylmalonate

p-chloroaniline

→

desired product

Ethyl 2-(4-chlorophenylcarbamoyl)butyrate

Disolventes

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture was cooled
2. 2
   Lavadofurther, the mixture was washed successively with 1N hydrochloric acid, aqueous sodium bicarbonate solution, and water
3. 3
   Concentraciónconcentrated under reduced pressure
4. 4
   Lavadoeluted with chloroform

Procedimiento

Diethyl 2-ethylmalonate (8.76 ml) and p-chloroaniline (4 g) were dissolved by heating at 130° C. for 11 hours, and the mixture was cooled and dissolved in ethyl acetate, and further, the mixture was washed successively with 1N hydrochloric acid, aqueous sodium bicarbonate solution, and water, and concentrated under reduced pressure. The resulting residue was subjected to column chromatography on silica gel and eluted with chloroform to give the oily desired product (6.66 g).

Fuente