Reacción #44628

Ecuación de reacción

methanol

(4R,9aS)-4-(3,4,5-trifluorophenyl)-3,4,7,9a-tetrahydro-1H-pyrido[2,1-c][1,4]oxazin-6-one

→

title compound

Rendimiento 100.1%

(4R,9aS)-4-(3,4,5-trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6-one

Rendimiento 100.1%

Disolventes

hydrogen

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe resulting reaction solution
2. 2
   Filtraciónfiltered through Celite
3. 3
   ConcentraciónThe filtrate was concentrated under reduced pressure

Procedimiento

Platinum oxide (20.1 mg) was added to a methanol solution (6 mL) of (4R,9aS)-4-(3,4,5-trifluorophenyl)-3,4,7,9a-tetrahydro-1H-pyrido[2,1-c][1,4]oxazin-6-one (250 mg). The resulting reaction solution was stirred at room temperature for 2 hr in hydrogen atmosphere and then filtered through Celite. The filtrate was concentrated under reduced pressure to give 252 mg of the title compound. The physical property values of this compound were as follows:

Fuente