Reacción #44520

Ecuación de reacción

mixture

ethyl 3-(4-amino-2-(methylsulfanyl)-1,3-thiazol-5-yl)-3-oxopropanoate

N,N-dimethyl-formamide dimethyl acetal

→

ethyl (2Z)-3-(dimethylamino)-2-((4-(((E)-(dimethylamino)methylidene)amino)-2-(methylsulfanyl)-1,3-thiazol-5-yl)carbonyl)-2-propenoate

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónconcentrated to half volume
2. 2
   Temperaturacooled
3. 3
   Filtraciónfiltered

Procedimiento

A mixture of EXAMPLE 1A (8.8 g) and N,N-dimethyl-formamide dimethyl acetal (15.1 g) in toluene (170 mL) at 110° C. was stirred for 3 hours, concentrated to half volume, cooled, and filtered. 1H NMR (300 MHz, CDCl3) δ 8.40 (s, 1H), 7.42 (s, 1H), 3.99 (q, 2H), 3.05 (d, 6H), 2.92 (b, 6H), 2.65 (s, 3H), 1.04 (t, 3H).

Fuente