Reacción #44518

Ecuación de reacción

6-(2-chloropyrimidin-4-yloxy)-N,2-dimethylbenzofuran-3-carboxamide

3-methoxyaniline

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title product

Rendimiento 80.0%

6-(2-(3-methoxyphenylamino)pyrimidin-4-yloxy)-N,2-dimethylbenzofuran-3-carboxamide

Rendimiento 80.0%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónsubjected to extraction with ethyl acetate
2. 2
   workup.ADDITIONThen water was added
3. 3
   Extracciónthe mixture was subjected to extraction with ethyl acetate
4. 4
   LavadoThe organic layer was washed with water and brine sequentially
5. 5
   Secadodried over anhydrous Na2SO4
6. 6
   Concentraciónconcentrated
7. 7
   OtroThe resulting residue was purified by column chromatography

Procedimiento

6-(2-chloropyrimidin-4-yloxy)-N,2-dimethylbenzofuran-3-carboxamide (0.1 mmol) and 3-methoxyaniline (0.1 mmol) were dissolved in 0.5 ml DMF. To this was added p-TsOH monohydrate (0.2 mmol). The reaction mixture was stirred at 60° C. for 5 hours, and subjected to extraction with ethyl acetate. Then water was added and the mixture was subjected to extraction with ethyl acetate. The organic layer was washed with water and brine sequentially, dried over anhydrous Na2SO4, and concentrated. The resulting residue was purified by column chromatography to provide the title product in a yield of 80%.

Fuente