Reacción #444192

Ecuación de reacción

water

5-(4-chlorobutylthio)imidazo[1,2-a]pyridine

oxazolidine-2,4-dione potassium salt

sodium iodide

→

desired product

3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]-oxazolidine-2,4-dione

Disolventes

N,N-dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling
2. 2
   Extracciónextracted with ethyl acetate
3. 3
   LavadoThe organic layer was washed with water
4. 4
   Otrodried
5. 5
   workup.DISTILLATIONafter which the solvent was distilled off
6. 6
   OtroThe residue was purified by column chromatography (eluent: ethyl acetate)

Procedimiento

To a solution of 6.30 g (26.2 mmol) of 5-(4-chlorobutylthio)imidazo[1,2-a]pyridine and 3.64 g (26.2 mmol) of oxazolidine-2,4-dione potassium salt in 100 ml of N,N-dimethylformamide, 3.92 g (26.2 mmol) of sodium iodide was added, followed by stirring at 80° C. for 16 hours. After cooling, the reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with water and dried, after which the solvent was distilled off. The residue was purified by column chromatography (eluent: ethyl acetate) to yield 5.70 g (71.4%, light orange crystal) of the desired product.

Fuente