Reacción #444183

Ecuación de reacción

water

5-(4-chlorobutylthio)imidazo[1,2-a]pyridine

thiazolidine-2,4-dione

1,8-diazabicyclo[5.4.0]-7-undecene

→

desired product

3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]-thiazolidine-2,4-dione

Disolventes

N,N-dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling
2. 2
   Extracciónextracted with ethyl acetate
3. 3
   Lavadowashed with water
4. 4
   Otrodried
5. 5
   workup.DISTILLATIONafter which the solvent was distilled off
6. 6
   OtroThe residue was purified by column chromatography (eluent: ethyl acetate)
7. 7
   OtroThe resulting crude crystal was purified by recrystallization (solvent: chloroform/diethyl ether)

Procedimiento

To a solution of 8.35 g (35.4 mmol) of 5-(4-chlorobutylthio)imidazo[1,2-a]pyridine and 4.15 g (35.4 mmol) of thiazolidine-2,4-dione in 200 ml of N,N-dimethylformamide, 5.30 ml (35.4 mmol) of 1,8-diazabicyclo[5.4.0]-7-undecene was added, followed by heating at 80° C. for 16 hours. After cooling, the reaction mixture was poured into water, extracted with ethyl acetate, washed with water and dried, after which the solvent was distilled off. The residue was purified by column chromatography (eluent: ethyl acetate). The resulting crude crystal was purified by recrystallization (solvent: chloroform/diethyl ether) to yield 10.01 g (88.0%, light orange crystal) of the desired product.

Fuente