Reacción #4436

Ecuación de reacción

6-(3,4-dimethoxyphenyl)-2-methyl-4-(1-piperazinyl)pyrimidine

triethylamine

2,4-dichloro-5-sulfamoylbenzoyl chloride

→

4-[4-(2,4-dichloro-5-sulfamoylbenzoyl)piperazin-1-yl]-6-(3,4-dimethoxyphenyl)-2-methylpyrimidine

Rendimiento 71.5%

Disolventes

chloroform

Condiciones de reacción

Tratamiento posterior

1. 1
   LavadoThe reaction mixture was washed with water
2. 2
   Secadodried over magnesium sulfate
3. 3
   Otroevaporated
4. 4
   OtroThe obtained mixture was chromatographed on silica gel eluting with chloroform-methanol mixture (49:1 v/v)

Procedimiento

To a solution of 6-(3,4-dimethoxyphenyl)-2-methyl-4-(1-piperazinyl)pyrimidine (0.8 g) in chloroform (10 ml) were added triethylamine (0.39 ml) and 2,4-dichloro-5-sulfamoylbenzoyl chloride (0.74 g), and the mixture was stirred at ambient temperature for 20 hours. The reaction mixture was washed with water, dried over magnesium sulfate, and evaporated. The obtained mixture was chromatographed on silica gel eluting with chloroform-methanol mixture (49:1 v/v), to give 4-[4-(2,4-dichloro-5-sulfamoylbenzoyl)piperazin-1-yl]-6-(3,4-dimethoxyphenyl)-2-methylpyrimidine (1.03 g).

Fuente