Reacción #44350

Ecuación de reacción

product

1,1-dimethylethyl [[3′,5-dichloro-4′-(methylsulfinyl)[1,1′-biphenyl]-2-yl]oxy]acetate

TFA

→

title compound

[[3′,5-Dichloro-4′-(methylsulfonyl)[1,1′-biphenyl]-2-yl]oxy]acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was removed in vacuo, water
2. 2
   workup.ADDITIONwas added
3. 3
   Extracciónthe mixture was extracted with dichloromethane (three times)
4. 4
   SecadoThe organic extracts were dried (MgSO4)
5. 5
   Otroevaporated
6. 6
   Otrotriturated with ether

Procedimiento

A solution of the product from step d) (73 mg) in TFA (3 ml) was stirred for 2 h. The solvent was removed in vacuo, water was added and the mixture was extracted with dichloromethane (three times). The organic extracts were dried (MgSO4), evaporated and triturated with ether to give the title compound (46 mg) as a white solid. M.p. 140-2° C.

Fuente