Reacción #44346

Ecuación de reacción

sodium thiomethoxide

5-bromo-2-fluorobenzotrifluoride

water

→

sub-title compound

Rendimiento 68.3%

4-bromo-1-(methylthio)-2-(trifluoromethyl)-benzene

Rendimiento 68.3%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónextracted with isohexane
2. 2
   LavadoThe organics were washed with brine
3. 3
   Otrodried
4. 4
   Concentraciónconcentrated in vacuo

Procedimiento

A mixture of sodium thiomethoxide (317 mg) and 5-bromo-2-fluorobenzotrifluoride (1.0 g) in DMF (4 ml) was heated at 50° C. for 1 h then poured into water and extracted with isohexane. The organics were washed with brine, dried and concentrated in vacuo to give the sub-title compound (762 mg).

Fuente