Reacción #44341

Ecuación de reacción

ethylamine

ATL146e

→

JR3037

Rendimiento 73.0%

5-{6-Amino-2-[3-(4-ethylcarbamoyl-cyclohexyl)-prop-1-ynyl]-purin-9-yl}-3,4-dihydroxytetrahydrofuran-2-carboxylic acid ethylamide

Rendimiento 73.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe flask was sealed
2. 2
   TemperaturaThe vessel was cooled to 0° C.
3. 3
   Otrothe ethylamine was removed in vacuo

Procedimiento

To a sealed tube containing 5 mL of freshly distilled ethylamine was added 10 mg (0.02 mmol) of ATL146e. The flask was sealed and allowed to stir at 60° C. for 80 hours. After this time the reaction was only about 50% complete by HPLC. The vessel was cooled to 0° C., opened, and the ethylamine was removed in vacuo to yield 4.5 mg (73%) of JR3037 as a white solid and the recovery of 4.0 mg of starting material after the residue was purified by RP-HPLC. 1H NMR (CD3OD-d4) δ. 13C NMR (CD3OD-d4) δ. APCI m/z (rel intensity) 500.8 (MH+, 100), 327.4 (3).

Fuente