Reacción #443138

Ecuación de reacción

dioxane

( 9 )

5-Fluoro-8-nitro-4-(1,3-dioxoisoindoline-2-yl)-1-tetralone

→

title compound

8-Amino-5-fluoro-4-(1,3-dioxoisoindoline-2-yl)-1-tetralone

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe catalyst was removed by filtration
2. 2
   Concentraciónthe filtrate was concentrated
3. 3
   Otroto obtain fractions
4. 4
   workup.ADDITIONcontaining the target compound
5. 5
   ConcentraciónThe fractions were concentrated

Procedimiento

To 320 mg of the compound prepared in (9) above were added 9 ml of dioxane and 15 ml of ethanol. The mixture was catalytically hydrogenated with 290 mg of 10% palladium-on-carbon. The catalyst was removed by filtration, the filtrate was concentrated, and the residue was subjected to silica gel column chromatography using hexane-ethyl acetate (2:1) as an eluant to obtain fractions containing the target compound. The fractions were concentrated to produce 206 mg of the title compound.

Fuente