Reacción #443131

Ecuación de reacción

( 4 )

3,8-Diacetylamino-5-methoxy-1-tetralone

sodium carbonate

→

title compound

3-Acetylamino-8-amino-5-methoxy-1-tetralone

Disolventes

hydrochloric acid

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling to 0° C.
2. 2
   Extracciónextracted with chloroform
3. 3
   SecadoThe extract was dried over magnesium sulfate
4. 4
   workup.ADDITIONmixed solvent as an eluant
5. 5
   Otroto obtain fractions
6. 6
   workup.ADDITIONcontaining the target compound
7. 7
   ConcentraciónThe fractions were concentrated

Procedimiento

102 mg of the compound prepared in (4) above was charged into 20 ml of 3N hydrochloric acid aqueous solution, and the mixture was heated at 60° C. for 2 hours while stirring. After cooling to 0° C., the reaction mixture was neutralized with sodium carbonate and extracted with chloroform. The extract was dried over magnesium sulfate, and subjected to silica gel column chromatography using an chloroform-methanol (40:1) mixed solvent as an eluant to obtain fractions containing the target compound. The fractions were concentrated to produce 66 mg of the title compound.

Fuente