Reacción #443129

Ecuación de reacción

( 3 )

2,8-Diacetylamino-1-tetralone

sodium carbonate

→

title compound

2-Acetylamino-8-amino-1-tetralone

Disolventes

hydrochloric acid

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling to 0° C.
2. 2
   Extracciónextracted with chloroform
3. 3
   SecadoThe extract was dried over magnesium sulfate
4. 4
   OtroThe residue obtained
5. 5
   Otroafter the removal of the solvent
6. 6
   Otrowas recrystallized in ethyl acetate

Procedimiento

245 mg of the compound prepared in (3) above was dissolved into 40 ml of 3N hydrochloric acid and heated at 60° C. for 1 hour while stirring. After cooling to 0° C., the reaction solution was neutralized with sodium carbonate and extracted with chloroform. The extract was dried over magnesium sulfate. The residue obtained after the removal of the solvent was recrystallized in ethyl acetate and hexane to obtain 150 mg of the title compound.

Fuente