Reacción #4424

Ecuación de reacción

2-chloro-3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-4-(2,4,6-trimethylphenylimino)pyrimidine

piperazine

→

3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-2-(1-piperazinyl)-4-(2,4,6-trimethylphenylimino)pyrimidine

Rendimiento 57.3%

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was refluxed for 3 hours
2. 2
   OtroThe mixture was evaporated
3. 3
   workup.DISSOLUTIONthe residue was dissolved in chloroform
4. 4
   Lavadowashed with aqueous sodium bicarbonate solution
5. 5
   SecadoThe organic layer was dried over magnesium sulfate
6. 6
   Otroevaporated
7. 7
   OtroThe residue was chromatographed on silica gel using
8. 8
   workup.ADDITIONa mixture of chloroform and methanol (95:5)

Procedimiento

To a suspension of 2-chloro-3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-4-(2,4,6-trimethylphenylimino)pyrimidine (1.07 g) in ethanol (10 ml) was added piperazine (0.70 g). The mixture was refluxed for 3 hours, cooled to ambient temperature. The mixture was evaporated, and the residue was dissolved in chloroform and washed with aqueous sodium bicarbonate solution. The organic layer was dried over magnesium sulfate and evaporated. The residue was chromatographed on silica gel using a mixture of chloroform and methanol (95:5) to give 3,4-dihydro-6-(3,4-dimethoxyphenyl)-3-methyl-2-(1-piperazinyl)-4-(2,4,6-trimethylphenylimino)pyrimidine (0.69 g).

Fuente