Reacción #442148

Ecuación de reacción

sodium borohydride

(4-chlorophenyl) (2-fluorophenyl)methanone

2-propanol

→

4-chloro-α-(2-fluorophenyl)benzenemethanol

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturarefluxing
2. 2
   workup.STIRRINGUpon completion, stirring
3. 3
   TemperaturaThe reaction mixture is cooled
4. 4
   OtroThe 2-propanol is evaporated
5. 5
   Extracciónthe residual product is extracted with trichloromethane
6. 6
   OtroThe extract is dried
7. 7
   Filtraciónfiltered
8. 8
   Otroevaporated

Procedimiento

To a stirred and refluxing mixture of 23.4 parts of (4-chlorophenyl) (2-fluorophenyl)methanone in 280 parts of 2-propanol are added portionwise 3.7 parts of sodium borohydride. Upon completion, stirring is continued for 2 hours at reflux temperature (±80° C.). The reaction mixture is cooled and decomposed by the addition of water. The 2-propanol is evaporated and the residual product is extracted with trichloromethane. The extract is dried, filtered and evaporated, yielding 4-chloro-α-(2-fluorophenyl)benzenemethanol as a residue.

Fuente