Reacción #441981

ord-1dce26dce88a41cd8e4c3cb6ab91d331

Ecuación de reacción

OC1CCN(c2nc(-c3ccccc3)nc3ccccc23)CC1
4-(4-hydroxypiperidinyl)-2-phenylquinazoline
[H-].[Na+]
sodium hydride
Fc1cccc2ccccc12
1-fluoronaphthalene
→
c1ccc(-c2nc(N3CCC(Oc4cccc5ccccc45)CC3)c3ccccc3n2)cc1
title compound
c1ccc(-c2nc(N3CCC(Oc4cccc5ccccc45)CC3)c3ccccc3n2)cc1
4-[4-(Naphthoxy)piperidinyl]-2-phenylquinazoline

Reactantes

OC1CCN(c2nc(-c3ccccc3)nc3ccccc23)CC1
4-(4-hydroxypiperidinyl)-2-phenylquinazoline
[H-].[Na+]
sodium hydride
Fc1cccc2ccccc12
1-fluoronaphthalene

Reactivos

Ninguno

Disolventes

CN(C)C=O
dimethylformamide

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

Equimolar quantities of 4-(4-hydroxypiperidinyl)-2-phenylquinazoline, sodium hydride and 1-fluoronaphthalene are heated in dimethylformamide to prepare the title compound.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US04377582uspto-grants-1983_03