Reacción #44157

Ecuación de reacción

Methanesulfonyl chloride

1-[3-(2-hydroxyethyl)phenyl]-2-pyrrolidinone

triethylamine

→

title compound

Rendimiento 93.0%

2-[3-(2-oxo-1-pyrrolidinyl)phenyl]ethyl methanesulfonate

Rendimiento 93.0%

Disolventes

dichloromethane

ethyl acetate

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with water (50 mL), aqueous hydrochloric acid (1N, 2×50 mL)
2. 2
   SecadoThe organic layer was dried over sodium sulfate
3. 3
   Concentraciónconcentrated under reduced pressure
4. 4
   OtroThe crude was purified by flash chromatography on silica gel
5. 5
   Lavadoeluting with ethyl acetate-cyclohexane (50:50)

Procedimiento

Methanesulfonyl chloride (0.124 mL) was added dropwise to a stirred solution of 1-[3-(2-hydroxyethyl)phenyl]-2-pyrrolidinone (0.30 g) and triethylamine (0.42 mL) in dichloromethane (10 mL) at room temperature under an inert atmosphere. The solution was stirred for 2 hours. The reaction mixture was diluted with ethyl acetate (50 mL) and washed with water (50 mL), aqueous hydrochloric acid (1N, 2×50 mL), a saturated aqueous solution of sodium hydrogencarbonate (50 mL) and brine (50 mL). The organic layer was dried over sodium sulfate and concentrated under reduced pressure. The crude was purified by flash chromatography on silica gel, eluting with ethyl acetate-cyclohexane (50:50) to afford the title compound in 93% yield (0.384 g).

Fuente